Antipsychotics affect patients with schizophrenia

The task that several drugs have is to treat the disease fairly. But what happens when instead of helping, this affects us? We can assume an allergy, but sometimes it is not so; for then the medicine is what is failing. This is what is happening with some atypical antipsychotics in people with schizophrenia.

schizophrenia is a mental disorder, chronic and qualified as serious, which consists of a design for the anomalous reality, which leads to a series of behaviors unusual, among which hallucinations or behaviors extravagant.

This has led to the difficulties of the patient to create goals and achieve goals, which can lead to problems to develop in the environment that surrounds them, and to establish social relations .

antipsychotic Medicines for schizophrenia

Scientists at the Centre of Biomedical Research Network on Mental Health (CIBERSAM) belonging to the University of the Basque Country (UPV / EHU), unfold the cellular mechanisms that explain cognitive deterioration after continued use, especially at high doses, antipsychotics atypical in people with schizophrenia.

antipsychotics are drugs that are originally (and mainly) used to treat patients with states schizophrenic, or psychotic, but are also used in bipolar disorders, dementia , symptoms or organic sedative powerful in cases of agitation or aggression psychomotor (reassure without changing the consciousness). neither produces an excitement paradoxical).

But the study revealed in Nature Neuroscience showed that the blocking of the serotonin receptor 5HT2A, caused by antipsychotic drugs, activates an important pathway inflammatory in the brain, that alters the morphology and function of the sipnasis responsible for the maintenance of cognitive activity dynamic, a phenomenon known as synaptic plasticity .

How they found it?

Through tests in cellular models, the brain tissue of deceased people with schizophrenia and genetically altered animals and subjected to medication treatments, have been detected anomalies in synaptic that induce cognitive impairments, such as difficulties in memory work and the ability to distinguish between objects known and new.

The study showed that this cognitive deficit is due to a remodeling of the expression in the brain of different genes motivated by changes in the activity of the protein HDAC2, which suppresses the expression of DNA.

Benefits of this study

Thanks to the study carried out by the experts, this can bring about change, a time that prepares the way for the promotion of design of the drug, even in the experimental phase, which can inhibit these proteins and thus block the damage cognitive caused by treatments antiseptics.

Effects in people with schizophrenia

Among the cognitive problems associated with treatments for schizophrenia, which could contribute to your chronic, would be the problems of sustained attention, lack of mental flexibility in performing tasks and the difficulties in the planning of future tasks.

Problems caused by atypical antipsychotics

treatment with antipsychotic medications, more modern than the typical, meant the disappearance of problems in the activity the locomotor of the patients, but also seems to generate in addition to cognitive problems, an increased risk of metabolic diseases such as obesity and type 2 diabetes, thus increasing the cardiovascular risk.

however, explains Javier Meana , a researcher in the UPV / EHU, “these treatments can’t be pulled out early because they facilitate the emergence of hallucinations and delusions. The challenge is to avoid adverse effects while maintaining the important effectiveness antipsychotic that they have”.