Identify one of the causative genes of Alzheimer’s disease

Washington, (EFE).- An international group of scientificígraphics has identified one of the causative genes of Alzheimer’s disease, a disease neurol’gica progressive and incurable..

The gene is SORL1, whose variations can’w be the factor that determines the initial development of the disease, which is characterized by the péloss progressive memory, dementia, and, for the &number;last, the death of patients.

The study was released today by the journal "Nature Genetics". In its report, the canadian researchers and the u.s. which made the análysis of the gene with the cooperation’n of scientificígraphics european and asiáticos, indicated that the new track genética, couldíto help to better understand the disease. S&number;n the scientific’graphics, the variations of the gene contribute to the development of platelet amyloid form in the brain of Alzheimer’s patients, for the mostíto people más of 65 to&years. "we do Not know well cuál is the cause of Alzheimer’s; but s’ we know that the factors geneéticos performance&bathrooms;an important role" in its development, indic’ Richard Hodes, director of the National Institute of as well as nursing homesíto US. Hodes&bath;adi’ that have, until now, habían identified three other genes, whose variaci’ve can’to be the cause of the onset of Alzheimer’s disease. "But this discovery provides a clue genética completely new about the early forms of this complex disease", he said’. In the study, funded by the National Institute of as well as nursing homesía, the National Institute of Research’n of the Human Genome and organizations, p&number;public-and private of several países, participated in más 6,000 volunteers who donated their blood so that they will conduct a análysis geneético. S&number;n Lindsay Farrer, professor of genética of the University of Boston, who rushed’ the study, together with Peter St. George-Hyslop of the University of Toronto (Canadaá), análysis determin’ the influence of the gene in all datasets and in all racial groups. S&number;n the researcher Ekaterina Rogaeva, the study revel’ alsoén two gene variants that están linked to increased risk of Alzheimer’s disease in groups éethnic different. The researcher of the Research Center for Neurodegenerative disorders at the University of Toronto expres’ that the alternatives illustrate the complexity genética of the disease. Además,&bathrooms;’, "has important implications for other similar studies dutyían be performed to establish the variations of SORL1 in databases with a history genéticos similar". According to Richard Mayeux, director of Research, Alzheimer’s at Columbia University, it is important to perform other studies to determine with certainty that their results can be generalised. “SORL1 represents another crucial piece in the puzzle of Alzheimer’s disease, but to identify mutations in the gene that causes the disease is the task that we have for the future",&bathrooms;’. EFE