MADRID, (EUROPA PRESS) A fármaco used to treat the cáncer increases the long-term memory and strengthened neural connections in the brain, s&number;n a study of the University of California, Irvine (united States), which is published in the journal ‘Journal of Neuroscience’. The researchers found that inhibitors of histone deacetylase (HDAC) inhibitors, currently used in trials clínicos to attack tumors cancerígenos, relax the structure of the proteína that organize and compact the DNA gene’mico, which allows a activaci’n más simple of genes involved in the storage of memory.
The discovery suggests that inhibitors of HDAC can’w strengthen memory in human and be a terapéuticos for people with Alzheimer’s disease and Huntington’s or sísevere Rubenstein-Taybi. S&number;n explains Marcelo Wood, director of the study, "we have shown for the first time that HDAC inhibitors applied directly to the hippocampus enhance memory and plasticity withoutáoptics of the brain and we now know a molecular mechanism through which this occurs". A complex proteínico called chromatin causes the DNA gene’mico is compressed in a way very similar to the cable of the teléfono. When the chromatin is loosened, the genes associated with memory can activate of the form más fácil. Previous studies have shown that the proteína CBP causes chromatin to relax, and by this facilitates the activaci’n of the genes required for the formation’n of the memory. The researchers placed the mice in a cámara and given current eléctricas, soft, and similar to flows who receive the human when they walk on a carpet and touch a doorknob. After that, the scientificígraphics injected inhibitors of HDAC in the brain of mice, in particular in the hippocampus, a region’re involved in memory-short term and long term. A d’afterés, the researchers again put the mice in the cámara to see if they remembered the place in which habían received the current. S&number;n the researchers, the mice treated with inhibitors of HDAC remained still in the place where the deposit’ más time that those who did not receive the fármaco, indicating that the mice treated habían formed memories más strong cámara that are not treated. Scientists’graphics alsoén examined the brain tissue and discovered that the neural connections in the hippocampus were higher in the samples treated with HDAC inhibitors. The researchers found that the proteína CBP debíto be present for HDAC inhibitors to improve memory. The analysis of mice engineered geneétically to lack of CBP, HDAC inhibitors did not improve memory. When CBP is blocked in humans occurs neurodegeneraci’re associated with Huntington’s disease and cognitive defects in the sísevere Rubenstein-Taybi. The HDAC inhibitors can’w help to overcome this blockage and lead to a better neural function in people with these disorders and even improve your memory.