células mother present in the médula ’it can’an be used to fight infection’re persistent tb, s&number;n suggests a study by the International Center for Engineeringía and BiologíGenética in New Delhi (India), which is published in the edition’re a digital magazine ‘Proceedings of the National Academy of Sciences’ (PNAS). Researchers have discovered that the tuberculosis bacterium can’to rely on the células mother to establish infections long-lasting in people. The bacteria escapes the immune system by hiding inside compartments called granulomas in the lung tissues infected.
Although individuals with healthy immune systems can develop defensive responses, bacteria proliferating within the granuloma and establish persistent infections that can be lethal. Scientists’graphics, led by Gobardhan Das, examined the mechanism of evasi’re immune allows bacteria to persist in mice and men. The authors found that the bacteria recruit células mesenchymal stem cells, which are often found in the médula ’is, so that they move to the places of infection’re in the spleen and lungs of infected mice. A phalanx p-vascularérica células madre strengthens the granulomas, protecting the bacterium from attack of the células immune. The células mother produce a variety of molémovies immunosuppressive, including the ácido n’trico, that s not’will avoid it to the células immune from the surrounding area but alsoén helps to keep the multiplicaci’n of the bacteria. The findings suggest that the tuberculosis bacteria can’to establish persistent infections as they contain the células of the immune system and the n&number;number of bacteria under within the granulomas. Therefore, the authors suggest that células mesenchymal stem cells couldían to serve as a possible target terapéutica for tuberculosis.